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jerma: if you play candy crush, you’ll see that it’s currently got about 50 people playing it. and if you play this game called “destiny: the game”, you’ll see that it’s currently got 2,000 people playing it. and if you play this game called mafia, you’ll see that it’s currently got 10,000 people playing it.
eosinophilic meningoencephalitis is a rare but highly morbid condition caused by eosinophils trapped in the brain parenchyma. in most cases, it develops in a patient with eosinophilia and existing neurological disorders. trauma is a common cause of eosinophilic meningoencephalitis. eosinophilic meningoencephalitis is almost always fatal, however, in some patients it can be self-limited or treatable with steroids. primary eosinophilic meningoencephalitis occurs in patients with no history of associated disorders or symptoms, i.e., those who have no known cause of their eosinophilia and no history of prior allergic symptoms.
although pemphigus foliaceus is the most common form of pemphigus, pemphigus vulgaris represents 10% to 25% of all pemphigus cases in western countries. it is thought to be a mucocutaneous disease characterized by blister formation affecting the oral, nasal and genital mucosa and may involve the conjunctiva. pemphigus vulgaris is an autoimmune blistering disease resulting from cross-reactive igg and iga antibodies against desmogleins 3 and 1, two transmembrane glycoproteins of the cornified epidermal cell plasma membrane. we characterized the antibody response of a patient with a blistering form of pemphigus vulgaris using sera from active and remitting disease states. indirect immunofluorescence demonstrated that the patient’s serum had antibody that bound both cultured normal human keratinocytes and desmoglein 3/1-transfected keratinocytes. the intensity of the fluorescence was directly proportional to the concentration of pemphigus vulgaris serum and the amount of igg antibody in the sample. this is the first report of an antibody response from pemphigus vulgaris that recognizes desmoglein 3/1.
jerma: if you play candy crush, you’ll see that it’s currently got about 50 people playing it. and if you play this game called “destiny: the game”, you’ll see that it’s currently got 2,000 people playing it. and if you play this game called mafia, you’ll see that it’s currently got 10,000 people playing it.
eosinophilic meningoencephalitis is a rare but highly morbid condition caused by eosinophils trapped in the brain parenchyma. in most cases, it develops in a patient with eosinophilia and existing neurological disorders. trauma is a common cause of eosinophilic meningoencephalitis. eosinophilic meningoencephalitis is almost always fatal, however, in some patients it can be self-limited or treatable with steroids. primary eosinophilic meningoencephalitis occurs in patients with no history of associated disorders or symptoms, i.e., those who have no known cause of their eosinophilia and no history of prior allergic symptoms.
although pemphigus foliaceus is the most common form of pemphigus, pemphigus vulgaris represents 10% to 25% of all pemphigus cases in western countries. it is thought to be a mucocutaneous disease characterized by blister formation affecting the oral, nasal and genital mucosa and may involve the conjunctiva. pemphigus vulgaris is an autoimmune blistering disease resulting from cross-reactive igg and iga antibodies against desmogleins 3 and 1, two transmembrane glycoproteins of the cornified epidermal cell plasma membrane. we characterized the antibody response of a patient with a blistering form of pemphigus vulgaris using sera from active and remitting disease states. indirect immunofluorescence demonstrated that the patient’s serum had antibody that bound both cultured normal human keratinocytes and desmoglein 3/1-transfected keratinocytes. the intensity of the fluorescence was directly proportional to the concentration of pemphigus vulgaris serum and the amount of igg antibody in the sample. this is the first report of an antibody response from pemphigus vulgaris that recognizes desmoglein 3/1.
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